Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old

Autor: Yingsi Zeng, Zijun Chen, Qinkai Chen, Xiaojiang Zhan, Haibo Long, Fenfen Peng, Fengping Zhang, Xiaoran Feng, Qian Zhou, Lingling Liu, Xuan Peng, null Evergreen Tree Nephrology Association, Guanhua Guo, Yujing Zhang, Zebin Wang, Yueqiang Wen, Jiao Li, Jianbo Liang
Rok vydání: 2020
Předmět:
Male
Neutrophils
medicine.medical_treatment
030232 urology & nephrology
Kaplan-Meier Estimate
Disease
030204 cardiovascular system & hematology
Gastroenterology
Leukocyte Count
0302 clinical medicine
Risk Factors
Pathology
RB1-214
Medicine
Cumulative incidence
Lymphocytes
education.field_of_study
Incidence
Incidence (epidemiology)
Middle Aged
Prognosis
Treatment Outcome
Cardiovascular Diseases
Female
Peritoneal Dialysis
Research Article
Adult
Risk
medicine.medical_specialty
Article Subject
Immunology
Population
Peritoneal dialysis
Young Adult
03 medical and health sciences
Internal medicine
Humans
Neutrophil to lymphocyte ratio
Risk factor
education
Proportional Hazards Models
Retrospective Studies
Inflammation
business.industry
Proportional hazards model
fungi
Cell Biology
Kidney Failure
Chronic
business
Biomarkers
Follow-Up Studies
Zdroj: Mediators of Inflammation, Vol 2020 (2020)
Mediators of Inflammation
ISSN: 1466-1861
0962-9351
Popis: Background. Neutrophil to lymphocyte ratio (NLR) is a new inflammatory marker; the relationship between NLR and adverse cardiovascular (CV) prognosis has been gradually emphasized in the general population. However, their association in peritoneal dialysis (PD) patients remains unclear. Methods. From January 1, 2010, to May 31, 2017, a total of 1652 patients were recruited. NLR was categorized in triplicates: NLR≤2.74, 2.743.96. Kaplan-Meier cumulative incidence curve and multivariable COX regression analysis were used to determine the relationship between NLR and the incidence of adverse CV outcome, while a competitive risk model was applied to assess the effects of other outcomes on adverse CV prognosis. Besides, forest plot was investigated to analyze the adverse CV prognosis in different subgroups. Results. During follow-up, 213 new-onset CV events and 153 CV disease (CVD) deaths were recorded. Multivariable COX regression models showed that the highest tertile of NLR level was associated with increased risk of CV events (HR=1.39, 95%CI=1.01‐1.93, P=0.046) and CVD mortality (HR=1.81, 95%CI=1.22‐2.69, P=0.003), while compared to the lowest tertile. Competitive risk models showed that the differences in CV event (P<0.001) and CVD mortality (P=0.004) among different NLR groups were still significant while excluding the effects of other outcomes. In subgroups, with each 1 increased in the NLR level, adjusted HR of new-onset CV event was 2.02 (95%CI=1.26−3.23, P=0.003) and CVD mortality was 2.98 (95%CI=1.58−5.62, P=0.001) in the younger group (age<60 years). Conclusions. NLR is an independent risk factor for adverse CV prognosis in PD patients younger than 60 years old.
Databáze: OpenAIRE
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