The oxidation of 8-oxo-7,8-dihydroguanine by iodine
| Autor: | Hiroshi Miyazawa, Rie Komori, Yoshihisa Sei, Takanobu Kobayashi, Masayuki Morikawa, Katsuhito Kino, Teruhiko Kobayashi |
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| Rok vydání: | 2009 |
| Předmět: |
Guanine
DNA damage Clinical Biochemistry Pharmaceutical Science chemistry.chemical_element Iodine Biochemistry Guanidines chemistry.chemical_compound 8 oxo 7 8 dihydroguanine Drug Discovery Organic chemistry Spiro Compounds Molecular Biology Diimine Aqueous solution Guanosine Hydantoins Organic Chemistry Diastereomer Potassium Iodide chemistry Molecular Medicine Oxidation-Reduction DNA DNA Damage |
| Zdroj: | Bioorganicmedicinal chemistry letters. 20(12) |
| ISSN: | 1464-3405 |
| Popis: | 8-Oxo-7,8-dihydroguanine was specifically oxidized by iodine with aqueous KI. Under acidic conditions, the major product was dehydro-guanidinohydantoin. Under basic conditions, two diastereoisomers of spirohydantoin were chiefly obtained. In addition, unstable diimine was detected for the first time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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