Metabolism of 4-androstene-3, 17β-diol-3-H3-4-C14 in human subjects
| Autor: | W.R. Slaunwhite, A.A. Sandberg, N. Kundu |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Male
medicine.medical_specialty Ketone Stereochemistry Clinical Biochemistry Alcohol In Vitro Techniques Urine Tritium Biochemistry chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Testosterone Molecular Biology Pharmacology chemistry.chemical_classification Carbon Isotopes organic chemicals Organic Chemistry food and beverages In vivo metabolism Metabolism Allylic alcohol chemistry Androgens Female |
| Zdroj: | Steroids. 6:543-551 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(65)90017-6 |
| Popis: | The in vivo metabolism of 4-androstene-3α, 17β-diol-3β-H3-4-C14 and of 4-androstene-3β, 17β-diol-3α-H3-4-C14 was investigated in normal subjects in order to ascertain the relative importance of two alternative pathways of reduction of ring A of testosterone, namely, reduction via the allylic alcohol versus reduction via the saturated ketone. If the allylic alcohol can be reduced directly to the saturated alcohol, the tritium at G3 will be retained. On the other hand, if the allylic alcohol must be oxidized to testosterone prior to reduction, the tritium at C3 will be eliminated. Analysis showed the latter pathway to be utilized almost exclusively. |
| Databáze: | OpenAIRE |
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