CD44v9 as a poor prognostic factor of triple-negative breast cancer treated with neoadjuvant chemotherapy

Autor: Chinami Koga, Kenichi Taguchi, Kimiko Baba, Sayuri Akiyoshi, Katsumi Takizawa, Aya Fujita, Yoshiaki Nakamura, Shinji Ohno, Mayumi Ishida, Wakako Tajiri, Hideki Ijichi, Takanobu Masuda, Eriko Tokunaga
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Neoplasm
Residual
medicine.medical_treatment
Vimentin
Triple Negative Breast Neoplasms
0302 clinical medicine
Surgical oncology
Antineoplastic Combined Chemotherapy Protocols
Protein Isoforms
Pharmacology (medical)
Breast
Triple-negative breast cancer
Mastectomy
biology
BRCA1 Protein
General Medicine
Middle Aged
Prognosis
Neoadjuvant Therapy
CD44v9
Hyaluronan Receptors
030220 oncology & carcinogenesis
Immunohistochemistry
Original Article
Female
Adult
medicine.medical_specialty
Neoadjuvant chemotherapy
Disease-Free Survival
03 medical and health sciences
Breast cancer
Internal medicine
medicine
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
Pathological
Cancer stemness
Aged
Chemotherapy
business.industry
Cancer
medicine.disease
030104 developmental biology
biology.protein
business
Zdroj: Breast Cancer (Tokyo, Japan)
ISSN: 1880-4233
1340-6868
Popis: Background Neoadjuvant chemotherapy (NAC) is the standard therapeutic strategy for triple-negative breast cancer (TNBC). TNBC patients with residual disease after NAC have a significantly worse survival than those with pathological complete response (pCR); however, there is no apparent prognostic factor for non-pCR patients. Cancer stemness or epithelial–mesenchymal transition (EMT) might influence the sensitivity to chemotherapy. Patients and methods Forty-eight patients with TNBC who were treated with NAC were available were included in this study. The expressions of stemness marker CD44v9, EMT marker vimentin and BRCA1, and basal phenotype were evaluated with immunohistochemistry. The relationships between the expression of these proteins and the pCR rate and the prognosis, especially in the patients with residual tumors, were investigated. Results Among the 48 patients, pCR was achieved in 14 cases. High nuclear grade and basal phenotype in the pre-NAC samples were significantly correlated with pCR (p = 0.0458 and 0.0343). There were no significant relationships between the pCR rate and the expression of CD44v9, vimentin, or BRCA1. Achieving pCR was significantly correlated with longer distant metastasis-free survival (DMFS) (p = 0.0206). High CD44v9 expression was significantly associated with shorter DMFS (p = 0.0291). Among the patients in whom pCR was not achieved, high grade in the residual tumor cells, poor pathological response and high CD44v9 expression in the pre-treatment CNB samples were significantly correlated with a poor DMFS (p = 0.0433, 0.0406 and p = 0.0333). In addition, high grade in the residual tumor cells was significantly associated with high CD44v9 expression in the pre-treatment CNB (p = 0.0389). Conclusions High CD44v9 expression in pre-NAC samples was associated with poor prognosis in TNBC patients treated with NAC, especially for those in whom pCR was not achieved. Electronic supplementary material The online version of this article (10.1007/s12282-018-0888-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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