Serum Caspase-1 as an Independent Prognostic Factor in Traumatic Brain Injured Patients

Autor: Javier Rodríguez Pilar, Osman Salazar, Juan Antonio Llompart-Pou, Juan Pablo de Rivero Vaccari, María Begoña Guardiola, Guillem Frontera, Mariana Andrea Novo, Javier Ibáñez, Catalina Crespí, Jon Pérez-Bárcena
Rok vydání: 2021
Předmět:
Zdroj: Neurocritical care. 36(2)
ISSN: 1556-0961
Popis: The objectives of this study were to assess the association between serum caspase 1 levels and known clinical and radiological prognostic factors and determine whether caspase 1was a more powerful predictor of outcome after traumatic brain injury (TBI) than clinical indices alone, to determine the association between the serum levels of caspase 1 and the 6-month outcome, and to evaluate if there is any association between caspase 1 with clinical and radiological variables. This prospective and observational study was conducted in a university hospital and included patients with TBI who required hospital admission. Serum samples were collected at hospital admission and 24 h after TBI. Caspase 1 levels were determined by enzyme-linked immunosorbent assay. Receiver operating characteristic curves were obtained to test the potential of caspase 1 to predict mortality (Glasgow Outcome Scale Extended score of 1) and unfavorable outcome (Glasgow Outcome Scale Extended scores of 1–4). Multivariate logistic regression was used to assess the effect of serum caspase 1 levels, adjusted by known clinical and radiological prognostic indices, on the outcome. One hundred thirty-two patients and 33 healthy controls were included. We obtained 6-month outcome in 118 patients. On admission, the mean serum levels of caspase 1 were higher in patients with TBI compared with controls (157.9 vs. 108.5 pg/mL; p
Databáze: OpenAIRE
Externí odkaz: