High levels of urinary complement proteins are associated with chronic renal damage and proximal tubule dysfunction in immunoglobulin A nephropathy

Autor: Henrik Birn, Jing Xiao, Lu Wen, Zheng Wang, Zhanzheng Zhao, Jon Waarst Gregersen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
IGA NEPHROPATHY
Male
030232 urology & nephrology
Kidney Tubules
Proximal/physiopathology
Complement Membrane Attack Complex
030204 cardiovascular system & hematology
urologic and male genital diseases
Gastroenterology
Pathogenesis
ACTIVATION
Kidney Tubules
Proximal
0302 clinical medicine
GLOMERULAR DEPOSITION
Complement Membrane Attack Complex/analysis
General Medicine
Middle Aged
urinary
Nephrology
Factor H
Complement Factor H
Female
Glomerular Filtration Rate
Adult
medicine.medical_specialty
FACTOR-H
MEGALIN
OXFORD CLASSIFICATION
Urinary system
proximal tubule dysfunction
Renal function
Mannose-Binding Lectin
Excretion
03 medical and health sciences
Internal medicine
MANNOSE-BINDING LECTIN
medicine
Humans
Renal Insufficiency
Chronic
complement proteins
immunoglobulin A nephropathy
business.industry
Glomerulonephritis
IGA
Mannose-Binding Lectin/blood
medicine.disease
Complement Factor H/analysis
Complement system
Renal Insufficiency
Chronic/etiology
Glomerulonephritis
IGA/complications
Complement membrane attack complex
business
chronic kidney disease
Kidney disease
Zdroj: Wen, L, Zhao, Z, Wang, Z, Xiao, J, Birn, H & Gregersen, J W 2019, ' High levels of urinary complement proteins are associated with chronic renal damage and proximal tubule dysfunction in immunoglobulin A nephropathy ', Nephrology (Carlton, Vic.), vol. 24, no. 7, pp. 703-710 . https://doi.org/10.1111/nep.13477
Wen, L, Zhao, Z, Wang, Z, Xiao, J, Birn, H & Gregersen, J W 2019, ' High levels of urinary complement proteins are associated with chronic renal damage and proximal tubule dysfunction in immunoglobulin A nephropathy ', Nephrology, vol. 24, no. 7, pp. 703-710 . https://doi.org/10.1111/nep.13477
DOI: 10.1111/nep.13477
Popis: Aim Complement activation is involved in the pathogenesis and progression of immunoglobulin A nephropathy (IgAN); however, the clinical implication of abnormal complement protein levels in serum and urine is not clear. To address this we analyzed the correlation between disease activity and complement proteins in serum and urine from IgAN patients, and compared to patients with other types of chronic kidney disease (CKD) as well as healthy controls. Methods We included 85 Chinese patients with IgAN, 23 patients with non-proliferative CKD, and 20 healthy individuals. Patients were divided according to the Oxford classification of M0E0S0T0 (group 1, n = 20), M1E1S0-1 T0-1 (group 2, n = 25), M1E1S0-1 T2 or M0E0S1T1-2 (group 3, n = 40). Complement factor H (CFH), mannose-binding lectin and membrane attack complex in serum and urine were measured by enzyme-linked immunosorbent assay. Results Urinary CFH, membrane attack complex and serum CFH were increased in both IgAN and CKD patients compared with healthy controls. The urinary excretion of CFH was the highest in IgAN patients with most tubulointerstitial damage (IgAN group 3). Urinary CFH and mannose-binding lectin levels were significantly higher in IgAN patients with crescents formation (C1-2) than in patients without (C0). Urinary complement protein excretion correlated negatively with estimated glomerular filtration rate, and positively with urinary retinol-binding protein and alpha 1-microglobulin excretion indicating proximal tubule dysfunction. Conclusion Increased urinary excretion of complement proteins in IgAN is related to chronic injury and tubular dysfunction. This warrants caution using urinary complement proteins as markers of disease activity.
Databáze: OpenAIRE
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