Adding methylphenidate to prism-adaptation improves outcome in neglect patients. A randomized clinical trial
Autor: | Alessandro Farnè, Sophie Ciancia, François Quelard, Patrick Hovantruc, Yann Cojan, Gilles Rode, Laurent Villeneuve, Yves Rossetti, Audrey Janoly-Dumenil, Sophie Jacquin-Courtois, Pierre-Olivier Sancho, Thierry Sarraf, François Cotton, Jacques Luauté, Stuart Nash, Dominique Boisson, Eric Chabanat, Adeline Roux, Fadila Hadj-Bouziane, Jean-Yves Bar |
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Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), Pôle Information Médicale Evaluation Recherche (IMER), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), ANR-11-IDEX-0007,Avenir L.S.E.,Construction, Fonction Cognitive et Réhabilitation du Cerveau(2011), ANR-10-IBHU-0003,CESAME,CESAME(2010), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Activities of daily living Randomised trials [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Cognitive Neuroscience media_common.quotation_subject [SDV]Life Sciences [q-bio] Experimental and Cognitive Psychology Placebo 050105 experimental psychology Neglect law.invention Perceptual Disorders 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method Prim adaptation law Activities of Daily Living medicine Humans 0501 psychology and cognitive sciences Attention Stroke ComputingMilieux_MISCELLANEOUS media_common 05 social sciences Rehabilitation Stroke Rehabilitation Recovery of Function medicine.disease Functional Independence Measure Adaptation Physiological 3. Good health Neuropsychology and Physiological Psychology Mood Space Perception Physical therapy Methylphenidate Psychology Prism adaptation 030217 neurology & neurosurgery |
Zdroj: | Cortex Cortex, Elsevier, 2018, 106, pp.288-298. ⟨10.1016/j.cortex.2018.03.028⟩ Cortex, Elsevier, 2018, 106, pp.288--298. ⟨10.1016/j.cortex.2018.03.028⟩ |
ISSN: | 0010-9452 |
Popis: | Spatial neglect is one of the main predictors of poor functional recovery after stroke. Many therapeutic interventions have been developed to alleviate this condition, but to date the evidence of their effectiveness is still scarce. Objective The purpose of this study was to test whether combining prism adaptation (PA) and methylphenidate (MP) could enhance the recovery of neglect patients at a functional level. Methods RITAPRISM is a multicentre, randomized, double-blind, placebo-controlled study comparing PA plus placebo (control) versus PA plus MP. 24 patients were prospectively enrolled (10 in the placebo group and 14 in the MP group). Results The main result is a long-term functional improvement (on the functional independence measure (FIM) and on Bergego's scale) induced by MP combined with PA. No serious adverse event occurred. Conclusions The long-term benefit on activities of daily living (ADL) obtained in this randomized controlled trial set this intervention apart from previous attempts and supports with a high level of evidence the value of combining PA and MP in order to improve the autonomy of neglect patients. Further studies will be needed to clarify the mechanism of this improvement. Although not specifically assessed at this stage, a part of the improvement in ADL might be related to the collateral effect of MP on mood, executive functions or fatigue, and/or the combined effect of PA and MP on motor intentional bias of neglect patients. Classification of evidence This study provides Class I evidence that adding MP to PA improves the functional outcome of neglect patients. WHO trial registration ID EUCTR2008-000325-20-FR. |
Databáze: | OpenAIRE |
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