Adding methylphenidate to prism-adaptation improves outcome in neglect patients. A randomized clinical trial

Autor: Alessandro Farnè, Sophie Ciancia, François Quelard, Patrick Hovantruc, Yann Cojan, Gilles Rode, Laurent Villeneuve, Yves Rossetti, Audrey Janoly-Dumenil, Sophie Jacquin-Courtois, Pierre-Olivier Sancho, Thierry Sarraf, François Cotton, Jacques Luauté, Stuart Nash, Dominique Boisson, Eric Chabanat, Adeline Roux, Fadila Hadj-Bouziane, Jean-Yves Bar
Přispěvatelé: Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), Pôle Information Médicale Evaluation Recherche (IMER), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), ANR-11-IDEX-0007,Avenir L.S.E.,Construction, Fonction Cognitive et Réhabilitation du Cerveau(2011), ANR-10-IBHU-0003,CESAME,CESAME(2010), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Activities of daily living
Randomised trials
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Cognitive Neuroscience
media_common.quotation_subject
[SDV]Life Sciences [q-bio]
Experimental and Cognitive Psychology
Placebo
050105 experimental psychology
Neglect
law.invention
Perceptual Disorders
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
Prim adaptation
law
Activities of Daily Living
medicine
Humans
0501 psychology and cognitive sciences
Attention
Stroke
ComputingMilieux_MISCELLANEOUS
media_common
05 social sciences
Rehabilitation
Stroke Rehabilitation
Recovery of Function
medicine.disease
Functional Independence Measure
Adaptation
Physiological
3. Good health
Neuropsychology and Physiological Psychology
Mood
Space Perception
Physical therapy
Methylphenidate
Psychology
Prism adaptation
030217 neurology & neurosurgery
Zdroj: Cortex
Cortex, Elsevier, 2018, 106, pp.288-298. ⟨10.1016/j.cortex.2018.03.028⟩
Cortex, Elsevier, 2018, 106, pp.288--298. ⟨10.1016/j.cortex.2018.03.028⟩
ISSN: 0010-9452
Popis: Spatial neglect is one of the main predictors of poor functional recovery after stroke. Many therapeutic interventions have been developed to alleviate this condition, but to date the evidence of their effectiveness is still scarce. Objective The purpose of this study was to test whether combining prism adaptation (PA) and methylphenidate (MP) could enhance the recovery of neglect patients at a functional level. Methods RITAPRISM is a multicentre, randomized, double-blind, placebo-controlled study comparing PA plus placebo (control) versus PA plus MP. 24 patients were prospectively enrolled (10 in the placebo group and 14 in the MP group). Results The main result is a long-term functional improvement (on the functional independence measure (FIM) and on Bergego's scale) induced by MP combined with PA. No serious adverse event occurred. Conclusions The long-term benefit on activities of daily living (ADL) obtained in this randomized controlled trial set this intervention apart from previous attempts and supports with a high level of evidence the value of combining PA and MP in order to improve the autonomy of neglect patients. Further studies will be needed to clarify the mechanism of this improvement. Although not specifically assessed at this stage, a part of the improvement in ADL might be related to the collateral effect of MP on mood, executive functions or fatigue, and/or the combined effect of PA and MP on motor intentional bias of neglect patients. Classification of evidence This study provides Class I evidence that adding MP to PA improves the functional outcome of neglect patients. WHO trial registration ID EUCTR2008-000325-20-FR.
Databáze: OpenAIRE
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