Multiparametric MRI Apparent Diffusion Coefficient (ADC) accuracy in diagnosing clinically significant prostate cancer
| Autor: | Pietro Pepe, Antonio Galia, Maria Gabriella Sabini, Giandomenico Priolo, Giorgio Ivan Russo, Filippo Fraggetta, L. M. Valastro, Michele Pennisi, Davide D’Urso, Antonio Garufi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Apparent diffusion coefficient (ADC) medicine.medical_treatment Gleason Score 6 General Biochemistry Genetics and Molecular Biology 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Medicine Effective diffusion coefficient Humans Multiparametric Magnetic Resonance Imaging Multiparametric MRI and prostate cancer Retrospective Studies Pharmacology Prostatectomy Receiver operating characteristic business.industry Area under the curve Prostatic Neoplasms Diffusion-weighted imaging (DWI) medicine.disease body regions medicine.anatomical_structure Diffusion Magnetic Resonance Imaging ROC Curve 030220 oncology & carcinogenesis Area Under Curve Radiology Neoplasm Grading business Research Article |
| Zdroj: | In vivo (Athens) 31 (2017): 415–418. doi:10.21873/invivo.11075 info:cnr-pdr/source/autori:Pepe Pietro 1, D'urso Davide 2, Garufi Antonio 3, Priolo Giandomenico 3, Pennisi Michele 1, Russo Giorgio 4, Sabini Maria Gabriella 2, Valastro Lucia Maria 2, Galia Antonio 5, Fraggetta Filippo 5/titolo:Multiparametric MRI Apparent Diffusion Coefficient (ADC) accuracy in diagnosing clinically significant prostate cancer/doi:10.21873%2Finvivo.11075/rivista:In vivo (Athens)/anno:2017/pagina_da:415/pagina_a:418/intervallo_pagine:415–418/volume:31 |
| Popis: | AIM: To evaluate the accuracy of multiparametric magnetic resonance imaging apparent diffusion coefficient (mpMRI ADC) in the diagnosis of clinically significant prostate cancer (PCa). PATIENTS AND METHODS: From January 2016 to December 2016, 44 patients who underwent radical prostatectomy for PCa and mpMRI lesions suggestive of cancer were retrospectively evaluated at definitive specimen. The accuracy of suspicious mpMRI prostate imaging reporting and data system (PI-RADS >=3) vs. ADC values in the diagnosis of Gleason score >=7 was evaluated. RESULTS: Receiver operating characteristics (ROC) curve analysis gave back an ADC threshold of 0.747×10-3 mm2/s to separate between Gleason Score 6 and >=7. The diagnostic accuracy of ADC value (cut-off 0.747×10-3 mm2/s) vs. PI-RADS score >=3 in diagnosing PCa with Gleason score >=7 was equal to 84% vs. 63.6% with an area under the curve (AUC) ROC of 0.81 vs. 0.71, respectively. CONCLUSION: ADC evaluation could support clinicians in decision making of patients with PI-RADS score |
| Databáze: | OpenAIRE |
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