Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880
| Autor: | Yasuyuki Asai, Naokazu Murahashi, Teruko Nomura, Kiyoshi Iwamoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Membrane Fluidity
Pyridinium Compounds Receptors Cell Surface Platelet Membrane Glycoproteins Micelle Chloride Receptors G-Protein-Coupled Surface tension Piperidines Drug Discovery Membrane fluidity medicine Surface Tension Molecule Particle Size Micelles Chromatography Chemistry General Chemistry General Medicine Lipids Critical micelle concentration Biophysics Particle size Platelet-activating factor receptor medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 48:947-950 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.48.947 |
| Popis: | E5880, a novel platelet activating factor receptor antagonist, was dispersed in water for the preparation of injectable formulation and the physicochemical properties of the micelles were characterized. The critical concentration for formation of micelles was 0.12 mM. Using the area per molecule results, the critical packing parameter was calculated and showed that the structure was composed of spherical micelles and the number of the molecules per micelle was 88. The diameter of a micelle was 8.1 nm. The fluidity and micropolarity around the hydrocarbon region of the micelles were evaluated and compared to the surfactants, stearyltrimethylammmonium chloride and cetyltrimethylammonium chloride. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|