Correlation of quantitative parameters of magnetic resonance perfusion-weighted imaging with vascular endothelial growth factor, microvessel density and hypoxia-inducible factor-1α in nasopharyngeal carcinoma: Evaluation on radiosensitivity study

Autor: Y. Hu, H. E, X. Yu, F. Li, L. Zeng, Q. Lu, X. Xi, L. Shen
Rok vydání: 2017
Předmět:
Adult
Male
Vascular Endothelial Growth Factor A
Oncology
medicine.medical_specialty
medicine.medical_treatment
Radiation Tolerance
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Humans
Medicine
Prospective Studies
Radiosensitivity
Prospective cohort study
Nasopharyngeal Carcinoma
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Area under the curve
Nasopharyngeal Neoplasms
Magnetic resonance imaging
Middle Aged
Hypoxia-Inducible Factor 1
alpha Subunit
medicine.disease
Vascular endothelial growth factor
Radiation therapy
Diffusion Magnetic Resonance Imaging
ROC Curve
Otorhinolaryngology
Nasopharyngeal carcinoma
chemistry
030220 oncology & carcinogenesis
Microvessels
Female
business
Zdroj: Clinical Otolaryngology. 43:425-433
ISSN: 1749-4478
Popis: OBJECTIVES To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN A prospective study. SETTING Department of Head-and-neck radiotherapy in Hunan Cancer Hospital. PARTICIPANTS Ninety-four patients of NPC were included between December 2013 and December 2014. MAIN OUTCOME MEASURES The expression of VEGF, MVD and HIF-1α was studied by immunohistochemistry, and magnetic resonance perfusion-weighted imaging (MR-PWI) was performed before and after undergoing radiotherapy (20 Gy dose). Parameters of MR-PWI, volume of primary tumour and rate of tumour remission were measured and calculated. Patients with primary local tumour were then divided into completely response group (CR group) and partially response group (non-CR group) according to tumour regression condition. Relevant parameters were analysed by Spearman, and diagnostic efficiency of radiosensitivity was analysed by receiver operating characteristic curve (ROC). RESULTS The expression of VEGF was positively correlated with MVD (r = .322,P
Databáze: OpenAIRE
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