Correlation of quantitative parameters of magnetic resonance perfusion-weighted imaging with vascular endothelial growth factor, microvessel density and hypoxia-inducible factor-1α in nasopharyngeal carcinoma: Evaluation on radiosensitivity study
Autor: | Y. Hu, H. E, X. Yu, F. Li, L. Zeng, Q. Lu, X. Xi, L. Shen |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Oncology medicine.medical_specialty medicine.medical_treatment Radiation Tolerance 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Humans Medicine Prospective Studies Radiosensitivity Prospective cohort study Nasopharyngeal Carcinoma medicine.diagnostic_test Receiver operating characteristic business.industry Area under the curve Nasopharyngeal Neoplasms Magnetic resonance imaging Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Vascular endothelial growth factor Radiation therapy Diffusion Magnetic Resonance Imaging ROC Curve Otorhinolaryngology Nasopharyngeal carcinoma chemistry 030220 oncology & carcinogenesis Microvessels Female business |
Zdroj: | Clinical Otolaryngology. 43:425-433 |
ISSN: | 1749-4478 |
Popis: | OBJECTIVES To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN A prospective study. SETTING Department of Head-and-neck radiotherapy in Hunan Cancer Hospital. PARTICIPANTS Ninety-four patients of NPC were included between December 2013 and December 2014. MAIN OUTCOME MEASURES The expression of VEGF, MVD and HIF-1α was studied by immunohistochemistry, and magnetic resonance perfusion-weighted imaging (MR-PWI) was performed before and after undergoing radiotherapy (20 Gy dose). Parameters of MR-PWI, volume of primary tumour and rate of tumour remission were measured and calculated. Patients with primary local tumour were then divided into completely response group (CR group) and partially response group (non-CR group) according to tumour regression condition. Relevant parameters were analysed by Spearman, and diagnostic efficiency of radiosensitivity was analysed by receiver operating characteristic curve (ROC). RESULTS The expression of VEGF was positively correlated with MVD (r = .322,P |
Databáze: | OpenAIRE |
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