ADAMTS proteases and the tumor immune microenvironment: Lessons from substrates and pathologies
| Autor: | Juan Carlos Rodríguez-Manzaneque, Rita Caracuel-Peramos, Silvia Redondo-García, Carlos Peris-Torres |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Proteases
Histology Tumor immune microenvironment Biophysics Inflammation Context (language use) Biochemistry ADAMTS proteases Article Extracellular matrix Immune system Genetics Disintegrin medicine Molecular Biology lcsh:QH301-705.5 Thrombospondin biology ADAMTS Cell Biology Cell biology lcsh:Biology (General) biology.protein medicine.symptom |
| Zdroj: | Matrix Biology Plus, Vol 9, Iss, Pp 100054-(2021) Matrix Biology Plus |
| ISSN: | 2590-0285 |
| Popis: | The relationship of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases with inflammatory processes was anticipated since their discovery. Although knowledge of these extracellular proteases in different contexts continues to grow, many questions remain unanswered. In this review, we summarize the most important studies of ADAMTSs and their substrates in inflammation and in the immune system of non-oncological disorders. In addition, we update the findings on cancer and highlight their emerging role in the tumor immune microenvironment. Although the overall functions of extracellular molecules are known to be modulated by proteolysis, specific activities attributed to intact proteins and cleaved fragments in the context of inflammation are still subject to debate. A better understanding of ADAMTS activities will help to elucidate their contribution to the immune phenotype and to open up new therapeutic and diagnostic possibilities. Highlights • ADAMTS proteases have been widely associated with inflammatory and immune-related conditions in non-oncological disorders. • Some well-known ADAMTS substrates have also been studied in immune-related diseases regardless of their proteolysis status. • From all ADAMTS proteases, only ADAMTS1 and ADAMTS4 have been directly connected with the tumor immune microenvironment. • Knowing their substrates is key to understanding immunomodulation by ADAMTSs and designing new strategies against cancer. |
| Databáze: | OpenAIRE |
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