High frequency of HLA-A*0207 subtype in Chinese population
| Autor: | D.-C. Shieh, B.-S. Yang, H.-L. Kuan, Dong-Tsamn Lin, K.-J. Kao |
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| Rok vydání: | 1996 |
| Předmět: |
Genetics
education.field_of_study China Immunology Population Taiwan Hematology Human leukocyte antigen Biology Phenotype Polymerase Chain Reaction law.invention HLA-A genomic DNA Gene Frequency law HLA-A2 Antigen Immunology and Allergy Humans Allele education Allele frequency Polymerase chain reaction Alleles |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0041-1132 |
| Popis: | Background: HLA-A2 is the most polymorphic and most common HLA phenotype found in various ethnic populations. Seventeen HLA-A2 subtypes have been reported and characterized by molecular techniques. Differences among these subtypes are limited to a few amino acids. Among them, HLA-A*0201 is the predominant subtype among whites. The results of a recent study, however, suggest that the HLA-A*0207 subtype may be present at a high frequency in the Chinese population. Study Design and Methods: To determine the exact frequency of the HLA-A*0207 Sep s1996 Septype in the Chinese population, genomic DNA samples obtained from 54 HLA-A2-positive Chinese in Taiwan were studied by using sequence-specific primers and polymerase chain reaction. Results: HLA-A*0207 was present in 56 percent of the studied subjects. The estimated gene frequency for HLA-A*0207 is 17.8 percent in the Chinese population. Conclusion: HLA-A*0207 is the most common HLA-A2 subtype among Chinese. The high frequency of the HLA-A*0207 allele in this population offers a unique opportunity to study the ways in which different HLA-A2 subtypes may influence the clinical outcome of allograft transplantation and the disease susceptibility of recipients. |
| Databáze: | OpenAIRE |
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