Incidence and impact of dysplasia at final resection margins in cancers of the oral cavity
| Autor: | Hitesh Singhvi, Komal Lamba, Deepa Nair, Natarajan Ramalingam, Arjun Singh, Sudhir Nair, Manish Mair, Munita Bal, Pankaj Chaturvedi |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Oral cavity Resection 03 medical and health sciences 0302 clinical medicine Recurrence medicine Humans 030223 otorhinolaryngology Retrospective Studies Mouth Hyperplasia business.industry Incidence Incidence (epidemiology) Margins of Excision General Medicine Middle Aged medicine.disease Margin status Survival Analysis Otorhinolaryngology Dysplasia 030220 oncology & carcinogenesis Resection margin Female Mouth Neoplasms Radiology Neoplasm Grading business |
| Zdroj: | Acta Oto-Laryngologica. 140:963-969 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.1080/00016489.2020.1785642 |
| Popis: | The literature often cites margin status as being free, close or involved by tumor but there is very sparse evidence of the relevance of dysplasia at resection margin.This is a retrospective review of 1700 treatment naïve oral squamous carcinoma patients who underwent surgery between January 2012 and December 2015. The study arm consisted of patients with dysplasia at final resection margin (D-FRM). Each of these patients were double propensity matched to obtain positive (P-FRM), close (C-FRM) and free final resection margins (F-FRM).There was no hazard discrimination in survival among the D-FRM and C-FRM (vs F-FRM; p-0.597, HR-1.207 (0.621-2.346) and p-0.075, HR-1.594 (0.947-2.684), respectively). A decreasing survival trend was observed as the grade and number of D-FRM margins increased. Although not significant, the addition of adjuvant therapy for D-FRM showed a trend towards improved survival outcomes compared to C-FRM, especially with chemotherapy. |
| Databáze: | OpenAIRE |
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