Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
| Autor: | Claes Ohlsson, Marie K. Lindberg, Karin Hollberg, Olle Vidal, Göran Andersson, Dennis B. Lubahn, David J. Baylink, Subburaman Mohan, Jan-Ake Gustafsson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Heterozygote Genotype medicine.drug_class medicine.medical_treatment Estrogen receptor Stimulation Biology Mice Bone Density Internal medicine medicine Animals Estrogen Receptor beta Growth Plate Insulin-Like Growth Factor I Estrogen receptor beta Mice Knockout Sex Characteristics Multidisciplinary Bone Development Tibia Growth factor Estrogen Receptor alpha Biological Sciences Skeleton (computer programming) Androgen receptor Mice Inbred C57BL Endocrinology Receptors Estrogen Estrogen Female Estrogen receptor alpha |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 97(10) |
| ISSN: | 0027-8424 |
| Popis: | Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERalpha-knockout (ERKO), ERbeta-knockout (BERKO), and double ERalpha/beta-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERalpha, but not ERbeta, mediates important effects of estrogen in the skeleton of male mice during growth and maturation. |
| Databáze: | OpenAIRE |
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