Effects of Vitamin E Deficiency on GSH-lnduced Swelling of Rat Liver Mitochondria
| Autor: | Joseph C. Street, Ralph M. Johnson, LeGrande C. Ellis, Sydney O. Alozie |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Azides Sucrose medicine.medical_specialty Cell Membrane Permeability Membrane permeability medicine.medical_treatment Respiratory chain Mitochondria Liver Mitochondrion General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Adenosine Triphosphate Oxygen Consumption Internal medicine medicine Animals Vitamin E Vitamin E Deficiency Cyanides Chemistry Caseins Povidone Glutathione Rats Endocrinology Dietary Proteins Vitamin E deficiency Swelling medicine.symptom Mitochondrial Swelling Adenosine triphosphate |
| Zdroj: | Experimental Biology and Medicine. 148:929-932 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-148-38662 |
| Popis: | Liver mitochondria from alphatocopherol deficient rats swell more rapidly, both spontaneously and in the presence of GSH, than those from control animals. The increased swelling of deficient mitochondria induced by GSH was completely eliminated when mitochondria were left longer than two hours at 0 degrees in the suspending medium. GSH-induced swelling of liver mitochondria from alpha-tocopherol deficient rats is reversed by ATP, polyvinyl pyrrolidone (PVP) and by oral administration alpha-tocopherol (2 mg/day per rat). Swelling of mitochondria in the above system was completely inhibited by the respiratory chain inhibitor, cyanide (.001 M), and partially by azide (0.001 M). We suggest that the swelling tendency of liver mitochondria from alpha-tocopherol deficient rats might be associated with an altered respiratory mechanism and/or an alteration in membrane permeability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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