The changes in the intervertebral disc after chemonucleolysis demonstrated by magnetic resonance imaging
| Autor: | MJ Gibson, J Buckley, R C Mulholland, BS Worthington |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Time Factors Adolescent Discography Chymopapain Sciatica medicine Humans Orthopedics and Sports Medicine Prospective Studies Intervertebral Disc medicine.diagnostic_test biology business.industry Intervertebral Disc Chemolysis Magnetic resonance imaging Intervertebral disc medicine.disease Surgery medicine.anatomical_structure Intervertebral Disc Displacement Acute Disease Discitis biology.protein Female medicine.symptom business Nuclear medicine |
| Zdroj: | The Journal of bone and joint surgery. British volume. 68(5) |
| ISSN: | 0301-620X |
| Popis: | Magnetic resonance imaging (MRI) of the spine produces images which reflect the chemical composition of the intervertebral disc. We have conducted a prospective study of the serial changes in the MRI appearance of the intervertebral disc after chemonucleolysis with the enzyme chymopapain. Fourteen patients were studied after single-level chemonucleolysis and the results compared with a control group of 17 discs in six patients who had diagnostic discography without enzyme insertion. A consistent pattern of gradual loss of signal from the nucleus pulposus culminating in complete loss of nuclear signal was seen in all cases after chemonucleolysis. Chymopapain therefore produced MRI changes analogous with premature gross disc degeneration. The rate at which this occurred varied; complete loss of signal took at least six weeks. Transitory minor end-plate changes were present in five patients, probably representing a mild chemical discitis. No similar changes were seen in the discography group. |
| Databáze: | OpenAIRE |
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