Blood Lead Levels and Neurodevelopmental Function in Perinatally HIV-Exposed, Uninfected Children in a U.S.-Based Longitudinal Cohort Study
| Autor: | Katherine Tassiopoulos, Yanling Huo, Joseph Braun, Paige L. Williams, Renee Smith, Ann Aschengrau, Sharon Nichols, Rohan Hazra, William A. Meyer, Katherine Knapp, Nagamah S. Deygoo, George R. Seage, null for the Pediatric HIV/AIDS Cohort S |
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| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty National Health and Nutrition Examination Survey Tenofovir Immunology Population Human immunodeficiency virus (HIV) Pathogenesis 010501 environmental sciences medicine.disease_cause 01 natural sciences 03 medical and health sciences 0302 clinical medicine Virology Medicine 030212 general & internal medicine Longitudinal cohort Risk factor education 0105 earth and related environmental sciences education.field_of_study business.industry Infectious Diseases In utero Antiretroviral medication business medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses. 33:919-928 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | While children's exposure to environmental lead in the United States has decreased, areas of elevated levels remain. Because lead exposure is a risk factor for developmental delays, it should be considered when studying neurodevelopmental effects of in utero antiretroviral medication (ARV) exposure in the growing population of perinatally HIV-exposed, uninfected (PHEU) children. We compared blood lead levels (BPb) in PHEU children enrolled in the Surveillance Monitoring of ART Toxicities (SMARTT) Study to U.S. children, assessed associations with neurodevelopment, and explored whether associations between in utero ARV and neurodevelopment are modified by BPb. Prevalence of elevated BPb (≥5 μg/dl) at ages 1–2 years was calculated by year and race/ethnicity and compared to that for children in the National Health and Nutrition Examination Survey (NHANES 2002–2010). Associations between elevated BPb and neurodevelopment at 1 and 3 years were assessed. Associations between ARVs (tenofovir disoproxil fumarate [TDF]; atazanavir) and neurodevelopment were evaluated within BPb level (≥5 μg/dl vs. |
| Databáze: | OpenAIRE |
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