Macrophage tumor killing: influence of the local environment

Autor:	John B. Hibbs, Weinberg Jb, Read R. Taintor, Harold A. Chapman
Rok vydání:	1977
Předmět:	Lymphokines Multidisciplinary Effector Macrophages Tumor cells Neoplasms Experimental Biology Mycobacterium bovis Culture Media Endotoxins Blood Immunology Cancer research BCG Vaccine Macrophage Cytotoxic T cell Local environment Trypsin Enzyme Inhibitors Toxoplasma Cells Cultured
Zdroj:	Science (New York, N.Y.). 197(4300)
ISSN:	0036-8075
Popis:	Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e31bd87a765bb345f2ed49fd55f114b https://pubmed.ncbi.nlm.nih.gov/327547 Zobrazit plný text záznamu