Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies
| Autor: | Yijun Ruan, Lin Zhang, Jibiao Zhang, Yuting Liu, Xianglian Yu, Yawen Zhang, Jiayi Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Emotions social anxiety disorder Review Audiology behavioral disciplines and activities 050105 experimental psychology Angular gyrus 03 medical and health sciences fMRI study 0302 clinical medicine Cognition Gyrus medicine Humans 0501 psychology and cognitive sciences Fusiform gyrus medicine.diagnostic_test 05 social sciences Social anxiety Public Health Environmental and Occupational Health Attentional control Brain Phobia Social Magnetic Resonance Imaging meta-analysis medicine.anatomical_structure Meta-analysis activity likelihood estimation Medicine Functional magnetic resonance imaging Psychology 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 5556, p 5556 (2021) |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Objective: The present meta-analysis aimed to explore the cognitive and neural mechanism of social anxiety disorder (SAD) from a whole-brain view, and compare the differences in brain activations under different task paradigms. Methods: We searched Web of Science Core Collection and other databases with the keywords related to social anxiety, social phobia, and functional magnetic resonance imaging (fMRI) for comparing persons with SAD to healthy controls and used the activation likelihood estimation method. Thirty-seven papers met the inclusion criteria, including 15 with emotional faces as stimuli, 8 presenting specific situations as stimuli, and 14 using other types of tasks as stimuli. Among these papers, 654 participants were in the SAD group and 594 participants were in the control group with 335 activation increase points and 115 activation decrease points. Results: Whole-brain analysis showed that compared with healthy controls, persons with SAD showed significantly lower activation of the left anterior cingulate gyrus (MNI coordinate: x = −6, y = 22, z = 38; p < 0.001). Sub-group analysis based on task indicated that when performing tasks with emotional faces as stimuli, persons with SAD showed significantly lower activation of the left cerebellar slope and fusiform gyrus (MNI coordinate: x = −26, y = −68, z = −12; p < 0.001), and significantly higher activation of the right supramarginal gyrus and angular gyrus, than healthy controls (MNI coordinate: x = 58, y = −52, z = 30; p < 0.001). Conclusion: Individuals with social anxiety disorder show abnormal activation in the cingulate gyrus, which is responsible for the process of attention control, and task type can influence the activation pattern. |
| Databáze: | OpenAIRE |
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