Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage
| Autor: | Bernd Puschendorf, Otto Dapunt, Jürgen Falkensammer, Johannes Mair, Peter Mair, Karl-Paul Vorderwinkler, J. Bleier |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Myocardial Reperfusion Injury Coronary circulation chemistry.chemical_compound Troponin T Troponin complex Coronary Circulation Internal medicine Troponin I medicine Humans Coronary Artery Bypass Creatine Kinase Coronary sinus Aged Myosin Heavy Chains biology Myoglobin business.industry Myocardium Biochemistry (medical) Middle Aged Troponin Cell Compartmentation Isoenzymes medicine.anatomical_structure Endocrinology chemistry Elective Surgical Procedures Heart Arrest Induced cardiovascular system biology.protein Cardiology Female Creatine kinase business |
| Zdroj: | Clinical Chemistry. 44:1912-1918 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | We investigated the net myocardial release of creatine kinase isoenzyme MB (CKMB), myoglobin, cardiac troponin T (cTnT), cardiac troponin I (cTnI), and cardiac β-type myosin heavy chain (β-MHC) into the coronary circulation after cardioplegic cardiac arrest in humans. Cardiac markers were measured in paired arterial, central venous, and coronary sinus blood in 19 patients undergoing elective coronary artery bypass grafting (CABG) before aortic cross-clamping and 1, 5, 10, and 20 min after aortic declamping. cTnT and cTnI were released into the coronary sinus in parallel to each other and almost simultaneously to myoglobin and CKMB within 20 min of reperfusion. In contrast, no β-MHC was released in the same patients during the study period. The average soluble cTnT and cTnI pools in right atrial appendages of 11 patients with right atrial and right ventricular pressures within reference values were comparable and were ∼8% of total myocardial troponin content. The soluble β-MHC pool was |
| Databáze: | OpenAIRE |
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