Tissue invasion and metastasis: Molecular, biological and clinical perspectives
| Autor: | Daniel Sliva, William G. Helferich, Mark E. Prince, H. Ungefroren, Gunjan Guha, Sophie Chen, Sarah K. Thompson, Hiromasa Fujii, S. Salman Ashraf, Xujuan Yang, Dipita Bhakta, Masaru Katoh, Massimo Zollo, Chandra S. Boosani, Asfar S. Azmi, Amr Amin, Frank Gieseler, W N Keith, Daniele Santini, Andrew James Sanders, Somaira Nowsheen, Malancha Sarkar, P. Dhawan, Alexandros G. Georgakilas, Daniela Spano, Dorota Halicka, Lin Ye, Francesco Pantano, Pochi R. Subbarayan, Elena Niccolai, Wen Guo Jiang, Alan Bilsland, Katia Aquilano, Amedeo Amedei, Kanya Honoki, Maria Rosa Ciriolo |
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| Přispěvatelé: | Jiang, Wg, Sanders, Aj, Katoh, M, Ungefroren, H, Gieseler, F, Prince, M, Thompson, Sk, Zollo, Massimo, Spano, Daniela, Dhawan, P, Sliva, D, Subbarayan, Pr, Sarkar, M, Honoki, K, Fujii, H, Georgakilas, Ag, Amedei, A, Niccolai, E, Amin, A, Ashraf, S, Ye, L, Helferich, Wg, Yang, X, Boosani, C, Guha, G, Ciriolo, Mr, Aquilano, K, Chen, S, Azmi, A, Keith, Wn, Bilsland, A, Bhakta, D, Halicka, D, Nowsheen, S, Pantano, F, Santini, D. |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Cancer metastasi Cancer therapy Disease Biology Metastasis Tight Junctions RC0254 Invasion Neoplasms medicine Humans Neoplasm Invasiveness Molecular Targeted Therapy Settore BIO/10 Neoplasm Metastasis Protein kinase B PI3K/AKT/mTOR pathway Urokinase Cancer Cancer metastasis Transforming growth factor beta medicine.disease Cadherins Antineoplastic Agents Phytogenic 3. Good health Immunology Cancer research biology.protein Plasminogen activator medicine.drug Signal Transduction |
| Zdroj: | Seminars in cancer biology. |
| ISSN: | 1096-3650 1044-579X |
| Popis: | Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast percentage of cancer patient mortality. While advances in this area have been made, the process of cancer metastasis and the factors governing cancer spread and establishment at secondary locations is still poorly understood. The current article summarizes recent progress in this area of research, both in the understanding of the underlying biological processes and in the therapeutic strategies for the management of metastasis. This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB-1) and transforming growth factor beta (TGF-β), together with inactivation of activator protein-1 (AP-1) and suppression of matrix metalloproteinase-9 (MMP-9) activity as key targets and the use of phytochemicals, or natural products, such as those from Agaricus blazei, Albatrellus confluens, Cordyceps militaris, Ganoderma lucidum, Poria cocos and Silybum marianum, together with diet derived fatty acids gamma linolenic acid (GLA) and eicosapentanoic acid (EPA) and inhibitory compounds as useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer. Together, these strategies could represent new, inexpensive, low toxicity strategies to aid in the management of cancer metastasis as well as having holistic effects against other cancer hallmarks. |
| Databáze: | OpenAIRE |
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