Comparison of the diagnostic accuracy of combined elastosonography and BRAF analysis vs cytology and ultrasonography for thyroid nodule suspected of malignancy
| Autor: | Maria Rosa Pelizzo, Susi Barollo, Davide Nacamulli, Federica Vianello, Isabella Negro, Maria Elisa Girelli, Giammaria Pennelli, Caterina Mian, Eric Casal Ide, Sara Watutantrige-Fernando, Franco Mantero, Massimo Rugge, Laura Zambonin, Lorena Nico |
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| Rok vydání: | 2012 |
| Předmět: |
Thyroid nodules
Adult Male medicine.medical_specialty endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism Biopsy Fine-Needle Cytological Techniques Diagnostic accuracy Malignancy Young Adult Endocrinology Cytology Medicine Humans Thyroid Neoplasms Thyroid Nodule Medical diagnosis Aged Retrospective Studies Ultrasonography Aged 80 and over business.industry Thyroid Nodule (medicine) Middle Aged medicine.disease medicine.anatomical_structure Female Radiology medicine.symptom business |
| Zdroj: | Clinical endocrinology. 77(4) |
| ISSN: | 1365-2265 |
| Popis: | SummaryObjective Diagnosing thyroid nodules preoperatively using traditional diagnostic tools – ultrasonography (US) and cytology – still carries a considerable degree of uncertainty, and surgery is recommended for a far from negligible number of patients simply for diagnostic purposes. Thyroid elastosonography (USE) and BRAF analysis have recently proved useful in detecting thyroid malignancies. The aim of this study is to establish whether combining USE and BRAF testing ameliorates preoperative diagnosis of thyroid nodule candidates for intervention by conventional approaches, thereby avoiding the need for diagnostic surgical procedures. Design and Patients We retrospectively analysed the files of 155 consecutive patients with 164 nodules, all assessed by ultrasonography, cytology, USE and BRAF testing, who underwent thyroid surgery. Results Of the 164 nodules, 74 (45%) were benign and 90 (55%) were malignant at final histology. Combining ultrasonography and cytology identified 21 (13%) as benign, 93 (57%) as malignant or probably malignant and 50 (30%) as ‘suspended’ (when the combined test was not able to classify the node as benign or malignant) with a 99% sensitivity, 28% specificity, 63% PPV, 95% NPV and 67% accuracy. Combining USE and BRAF testing indicated that 59 (36%) were benign, 74 (45%) were malignant and 31 (19%) were in a ‘suspended’ category, with a 95% sensitivity, 74% specificity, 82% PPV, 93% NPV and 86% accuracy. Conclusions In assessing thyroid nodules suspected of malignancy, the combined analysis of USE and BRAF is equally sensitive and more specific than conventional procedures, achieving more accurate preoperative diagnoses than US and cytology combined. USE and BRAF analysis for thyroid nodule evaluation might reduce the number of unnecessary surgical procedures. |
| Databáze: | OpenAIRE |
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