Evaluation of the anthelminthic potential of Duranta erecta L. (Verbenaceae) fruits used in Nigerian ethnomedicine as a vermifuge
| Autor: | Chukwunyere Okwudiri Nwosu, Terry A. Nzeakor, Munachimso Ihuoma Udobi, Ifeanyi G. Eke, Amaechi Onyeabor, I. O. Ezeh, I. K. Idika |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Erythrocytes Time Factors Adult worm Nigeria Biology Albendazole 01 natural sciences Lethal Dose 50 03 medical and health sciences Feces Mice Drug Discovery Verbenaceae medicine High doses Animals Parasite Egg Count Strongylida Infections Pharmacology Anthelmintics Plants Medicinal Traditional medicine 010405 organic chemistry Plant Extracts medicine.disease biology.organism_classification Acute toxicity 0104 chemical sciences Disease Models Animal 030104 developmental biology Duranta erecta Fruit Strongylida Medicine Traditional Ethnomedicine Malaria medicine.drug Phytotherapy |
| Zdroj: | Journal of ethnopharmacology. 216 |
| ISSN: | 1872-7573 |
| Popis: | Ethnopharmacological relevance Duranta erecta L. fruits have been reported to have in vitro anthelminthic properties. People living in the tropical South-Eastern part of Nigeria use the plant in folk medicine for the treatment of malaria, abscesses and as a vermifuge. Although there are a few reports about its in vitro anthelminthic activity against different worm categories, scientific reports regarding its in vivo anthelminthic activity are limited. Aim of the study This study was designed with the aim of determining the potential of the plant as an anthelminthic and to verify the claims made by its local users. Materials and methods Acute toxicity of the plant extract was determined using Lorke's method. Anthelminthic activity was investigated using adult male albino mice experimentally infected with Heligmosomoides bakeri infective L3. Graded ascending doses of the plant extract and Albendazole respectively were orally administered to the mice in the infected groups. Corprological and haematological parameters were recorded within the study period. Twenty-eight (28) days post-infection, all infected mice were humanely sacrificed and the Post-Mortem Adult Worm Burden (WB) was estimated and recorded. Results The results showed that the extract had an LD50 greater than 5000 mg/kg BW and therefore was not acutely toxic for oral use. It also showed that the plant extract was unable to eliminate the faecal egg output or adult worms in the gastrointestinal tract of infected animals even at the high doses used in the study. This was in contrast to Albendazole which significantly (p Conclusion As a result of the poor anthelminthic effects recorded in the study, it is therefore recommended that Duranta erecta L. fruits be explored for its other useful effects rather than as an anthelminthic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect