Gd-Si oxide nanoparticles as contrast agents in magnetic resonance imaging
| Autor: | Jesús Pacheco-Torres, Alejandro Vidal-Moya, Pablo Botella, Angela Bernabeu, Eduardo Fernández, Alejandro Cabrera-García, Elisa Checa-Chavarria |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Fundación 'la Caixa' |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility General Chemical Engineering Oxide Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Electron Microscopy Service of the UPV Article lcsh:Chemistry Gd-Si nanoparticles chemistry.chemical_compound Nuclear magnetic resonance Magnetic resonance imaging Atom Prussian Blue analogues medicine General Materials Science Prussian blue medicine.diagnostic_test 021001 nanoscience & nanotechnology equipment and supplies 0104 chemical sciences Prussian blue analogues Contrast agent chemistry lcsh:QD1-999 Magnetic nanoparticles Nanorod 0210 nano-technology magnetic resonance imaging contrast agent human activities |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname Nanomaterials, Vol 6, Iss 6, p 109 (2016) Nanomaterials r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) Nanomaterials; Volume 6; Issue 6; Pages: 109 r-FISABIO. Repositorio Institucional de Producción Científica |
| ISSN: | 2079-4991 |
| Popis: | This article belongs to the Special Issue Nanomaterials for Cancer Therapies. We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+ solutions, which significantly improves the sensitivity of in vivo magnetic resonance images. The authors thank the Spanish MINECO (projects MAT2012-39290-CO2-01 and MAT2012-39290-CO2-02) for financial support. A.C.-G. also thanks “La Caixa” Foundation for a Ph.D. scholarship. |
| Databáze: | OpenAIRE |
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