Associations of salivary cortisol levels with metabolic syndrome and its components: the multi-ethnic study of atherosclerosis
| Autor: | Teresa E. Seeman, Brisa N. Sánchez, Steven Shea, Anjum Hajat, Nancy S. Jenny, Amy Soo Jin DeSantis, Sherita Hill Golden, Ana V. Diez-Roux |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Cortisol awakening response Waist Hydrocortisone Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Ethnic group Psychological intervention Context (language use) Blood Pressure Biochemistry Endocrinology Risk Factors Internal medicine medicine Humans Endocrine Research education Saliva Aged Aged 80 and over Metabolic Syndrome education.field_of_study business.industry Biochemistry (medical) Middle Aged medicine.disease Atherosclerosis Blood pressure Cross-Sectional Studies Female Metabolic syndrome Waist Circumference business Lipoproteins HDL |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 96(11) |
| ISSN: | 1945-7197 |
| Popis: | Prior research has identified associations between social-environmental factors and metabolic syndrome (MetS) components. The physiological mechanisms underlying these associations are not fully understood, but alterations in activity of the hypothalamic-pituitary-adrenal axis, a stress-responsive biological system, have been hypothesized to play a role.The aim of the study was to determine whether MetS diagnosis and specific clusters of MetS components (waist circumference, high-density lipoproteins, glucose, and blood pressure) are associated with cortisol levels.We conducted cross-sectional analyses of data from the Multi-Ethnic Study of Atherosclerosis (MESA) study in the general community.We studied a population-based sample of 726 adults (ages 48 to 89 yr) who do not have clinical diabetes.There were no interventions.Cortisol awakening response, cortisol decline across the waking day, and total cortisol output were analyzed (using 18 timed measures of salivary cortisol over 3 d).Overall, we found little evidence that the presence of MetS or its components is related to cortisol output or patterns. Contrary to expectation, the presence of MetS was associated with lower rather than higher area under the curve, and no consistent pattern was observed when MetS components or subsets of components were examined in relation to cortisol.Our findings do not support the hypothesis that differences in level or diurnal pattern of salivary cortisol output are associated with MetS among persons without clinical diabetes. |
| Databáze: | OpenAIRE |
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