A COMPARISON OF ORAL ONDANSETRON SYRUP OR INTRAVENOUS ONDANSETRON LOADING DOSE REGIMENS GIVEN IN COMBINATION WITH DEXAMETHASONE FOR THE PREVENTION OF NAUSEA AND EMESIS IN PEDIATRIC AND ADOLESCENT PATIENTS RECEIVING MODERATELY/HIGHLY EMETOGENIC CHEMOTHERAPY
| Autor: | F. Breatnach, Les White, C. J. McKenna, N. Zhestkova, S. A. Daly, T. Mitchell, C. Leal, V. Smelhaus, J. Ninane, I.-J. Hung, C. Haigh, J. Kowalczyk |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Adolescent Vomiting Nausea medicine.drug_class Administration Oral Antineoplastic Agents Placebo Loading dose Dexamethasone Ondansetron Route of administration Neoplasms medicine Humans Antiemetic Child Infusions Intravenous business.industry Infant food and beverages Hematology Treatment Outcome Oncology Child Preschool Anesthesia Pediatrics Perinatology and Child Health Antiemetics Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | Pediatric Hematology and Oncology. 17:445-455 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.1080/08880010050120791 |
| Popis: | This double-blind, parallel-group, multicenter study compared the efficacy and safety of intravenous (i.v.) ondansetron with oral syrup ondansetron plus oral dexamethasone in the prevention of nausea and emesis in pediatric patients receiving moderately/highly emetogenic chemotherapy. On each day of chemotherapy, patients were administered ondansetron 5 mg/m2 i.v. and placebo syrup orally (n = 215) or ondansetron 8 mg syrup orally and placebo i.v. (n = 223) plus dexamethasone 2-4 mg p.o. Ondansetron 4 mg syrup p.o. was administered twice daily for 2 days following the cessation of chemotherapy. Complete or major control of emesis was obtained in 89% patients in the i.v. group and 88% patients in the oral syrup group during the worst day of chemotherapy treatment (90% CI: -6, 4) and in 85% and 82% patients, respectively, during the worst day of the study period (90% CI: -8, 3). Intravenous or oral syrup ondansetron plus dexamethasone was well tolerated and effective in preventing chemotherapy-induced emesis in pediatric patients. |
| Databáze: | OpenAIRE |
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