World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction
| Autor: | Ardita Aliko, Andy Wolff, AM Lynge Pedersen, Revan Kumar Joshi, Nagamani Narayana, Siri Beier Jensen, Doron J. Aframian, Richard McGowan, Alessandro Villa, Ying Wai Sia, Colin Dawes, Jörgen Ekström, Gordon Proctor, Alexander Ross Kerr, Arjan Vissink |
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| Rok vydání: | 2016 |
| Předmět: |
SEASONAL ALLERGIC RHINITIS
Saliva Drug-Related Side Effects and Adverse Reactions salivary glands Oral Medicine TOLTERODINE EXTENDED-RELEASE Placebo-controlled study Salivary Gland Diseases GENERALIZED ANXIETY DISORDER PLACEBO-CONTROLLED TRIAL RANDOMIZED DOUBLE-BLIND Bioinformatics VASOACTIVE-INTESTINAL-PEPTIDE 03 medical and health sciences 0302 clinical medicine Quality of life QUALITY-OF-LIFE Humans Medicine General Dentistry saliva Salivary gland ATTENTION-DEFICIT/HYPERACTIVITY DISORDER business.industry Genitourinary system pathogenesis CHOLINESTERASE INHIBITOR PHYSOSTIGMINE 030206 dentistry Systematic review medicine.anatomical_structure Otorhinolaryngology physiology Immunology HUMAN PAROTID-GLAND business Oral medicine 030217 neurology & neurosurgery |
| Zdroj: | Oral Diseases. 22:365-382 |
| ISSN: | 1354-523X |
| Popis: | The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology. |
| Databáze: | OpenAIRE |
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