High antitrypanosomal activity of plant-derived sulphur-containing amides
| Autor: | Brigitte Brem, Julia Walochnik, Adriane Raninger, Walther H. Wernsdorfer, Harald Greger, Andreas Obwaller, Florian Astelbauer, Michael Duchêne |
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| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Drug Chagas disease Trypanosoma cruzi media_common.quotation_subject Antiprotozoal Agents Pharmacology Biology Inhibitory Concentration 50 Amphotericin B medicine Humans Pharmacology (medical) EC50 media_common Sulfur Compounds Plant Extracts Biological activity General Medicine Plants medicine.disease biology.organism_classification Amides Infectious Diseases Benznidazole Trypanosomiasis medicine.drug |
| Zdroj: | International Journal of Antimicrobial Agents. 36:570-572 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2010.07.003 |
| Popis: | Chagas disease, caused by Trypanosoma cruzi, represents an important public health problem in endemic geographic regions in Middle and South America, affecting 15 million infected people. Treatment options are still limited due to the toxicity of available drugs, parasite resistance and poor drug activity during the chronic phase of the disease. In this study, we investigated the in vitro antitrypanosomal activity of 15 tropical plant-derived compounds with the aim of finding new drug candidates. Three novel sulphur-containing amides (methyldambullin, methylgerambullin and sakambullin) showed promising antitrypanosomal activities, with 50% effective concentrations (EC₅₀ values) after 72 h exposure of 1.7, 1.23 and 5.18 μM, respectively, compared with EC₅₀ values for amphotericin B and benznidazole of 0.71 μM and 30.89 μM, respectively. |
| Databáze: | OpenAIRE |
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