Naloxone-induced hypoalgesia: Effects of noradrenergic antagonists and agonist
| Autor: | Westbrook Rf, H. Foo |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Agonist medicine.medical_specialty Hot Temperature medicine.drug_class Clinical Biochemistry Pain Propranolol (+)-Naloxone Pharmacology Toxicology Biochemistry Clonidine Norepinephrine Behavioral Neuroscience Internal medicine Prazosin medicine Animals Biological Psychiatry Hypoalgesia Naloxone Narcotic antagonist Chemistry Yohimbine Rats Inbred Strains Rats Endocrinology Sensory Thresholds medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 39:795-797 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(91)90167-z |
| Popis: | The present experiments confirmed that rats injected with naloxone and exposed to a heated floor acquired a hypoalgesic response, as indexed by the latencies to lick their paws. The expression of these latencies were unaffected by yohimbine, clonidine, propranolol, or by relatively moderate doses of prazosin, suggesting that the conditioned hypoalgesic response induced by pairings of naloxone and a heated floor is not mediated by the release and turnover of noradrenaline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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