A uniquely high level of recombination at the HLA-B locus
| Autor: | Ronald E. Bontrop, Xiaomin Liu, T. L. Garber, Jonathan E. Boyson, Stephen McAdam, David I. Watkins, Austin L. Hughes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Pan troglodytes
Molecular Sequence Data Receptors Antigen T-Cell Locus (genetics) Human leukocyte antigen Major histocompatibility complex Polymerase Chain Reaction Chimpanzee genome project Major Histocompatibility Complex HLA-B Antigens Animals Humans Amino Acid Sequence Allele Phylogeny DNA Primers Genetics Recombination Genetic Multidisciplinary Polymorphism Genetic biology Base Sequence Sequence Homology Amino Acid Bonobo Hominidae Exons biology.organism_classification biology.protein Gene polymorphism Research Article |
| Popis: | Major histocompatibility complex (MHC) loci are some of the most polymorphic genes in the animal kingdom. Recently, it has been suggested that although most of the human MHC loci are relatively stable, the HLA-B locus can undergo rapid changes, especially in isolated populations. To investigate the mechanisms of HLA-B evolution we have compared the sequences of 19 HLA-B homologues from chimpanzees and bonobos to 65 HLA-B sequences. Analysis of the chimpanzee and bonobo HLA-B homologues revealed that despite obvious similarities between chimpanzee and human alleles in exon 2, there was little conservation of exon 3 between humans and the two chimpanzee species. This finding suggests that, unlike all other HLA loci, recombination has characterized the HLA-B locus and its homologues for over 5 million years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|