A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti-secretary, mucoprotective and IL-10 mediated anti-inflammatory mechanisms
| Autor: | Chandraprakash Serkad, Harsha Mysore Rajagopal, Srikanta Belagihalli Manjegowda, Shylaja M. Dharmesh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Peptic Ulcer medicine.drug_class Anti-Inflammatory Agents Inflammation Pharmacology medicine.disease_cause Biochemistry Anti-inflammatory Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Curcuma Structural Biology medicine Animals Prostaglandin E2 Rats Wistar Molecular Biology biology Helicobacter pylori Chemistry Mucin General Medicine biology.organism_classification Anti-Bacterial Agents Interleukin-10 Rats Interleukin 10 030104 developmental biology biology.protein Pectins 030211 gastroenterology & hepatology Cyclooxygenase medicine.symptom Oxidative stress medicine.drug |
| Zdroj: | International journal of biological macromolecules. 118 |
| ISSN: | 1879-0003 |
| Popis: | Antiulcer potency of structurally defined low molecular weight modified pectin from turmeric (MTrPP) including inhibitory effects on H. pylori has been demonstrated previously by us. Given that ulcer is a disorder characterized by inflammatory responses leading to initiation, aggravation and perpetuation of disease conditions, the present study aims to understand the possible anti– inflammatory mechanisms through which MTrPP delivered antiulcer effects. Rats triggered with early phase gastric inflammation (LPS) followed by ulcer induction (swim–stress) were pretreated with MTrPP (150 mg/kg b.w) for 14 days. Inflammation and ulcer–specific markers were screened to assess the protective effects. MTrPP offered up to 91% protection by limiting the production of pro–inflammatory factors (TNF–α, IL–8, NF–кB) and by the tight differential regulation of cyclooxygenase (COX–1, 2), mitogen–activated–protein–kinase (p–p38, p–ERK– 1/2) and matrix metalloproteinase (pro–MMP–9). MTrPP showed modulatory effects through inhibition of galectin–3, oxidative stress, H+,K+–ATPase and elicitation of gastro–protective mediators such as, mucin, prostaglandin E2, NOx, zinc, IgA etc. Results revealed that MTrPP mediated the overall protection by creating an environment conducive to protection by switching from the inflammatory to anti–inflammatory phase via IL–10 over expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect