Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden
| Autor: | Kirk E. Hevener, Idalia Zamora, Xiaoqian Wu, Sudip Adhikari, Julian G Hurdle, Uyen Dang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030106 microbiology Microbial Sensitivity Tests Drug resistance Biology Rifaximin Microbiology Bacterial genetics 03 medical and health sciences chemistry.chemical_compound Mechanisms of Resistance RNA polymerase Drug Resistance Bacterial polycyclic compounds medicine Humans Pharmacology (medical) Enterocolitis Pseudomembranous Dominance (genetics) Pharmacology Enterocolitis Clostridioides difficile Rifamycin DNA-Directed RNA Polymerases Clostridium difficile Rifamycins Anti-Bacterial Agents 030104 developmental biology Infectious Diseases chemistry Mutation medicine.symptom |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 60:5604-5607 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01137-16 |
| Popis: | We characterized clinically occurring and novel mutations in the β subunit of RNA polymerase in Clostridium difficile ( Cd RpoB), conferring rifamycin (including rifaximin) resistance. The Arg 505 Lys substitution did not impose an in vitro fitness cost, which may be one reason for its dominance among rifamycin-resistant clinical isolates. These observations were supported through the structural modeling of Cd RpoB. In general, most mutations lacked in vitro fitness costs, suggesting that rifamycin resistance may in some cases persist in the clinic. |
| Databáze: | OpenAIRE |
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