Antiproliferative effect of (2'-5') oligoadenylate distinct from that of interferon in lymphoid cells
| Autor: | T. Leanderson, R. Nordfelth, Erik Lundgren |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cell type
Time Factors Biophysics Oligonucleotides Spleen Biology Lymphocyte Activation Biochemistry Mice Interferon medicine 2' 5'-Oligoadenylate Synthetase Concanavalin A Animals Lymphocytes Molecular Biology Oligoribonucleotides 2'-5'-Oligoadenylate Adenine Nucleotides Cell Cycle Cell Biology Cell cycle Molecular biology Reaction product medicine.anatomical_structure Enzyme Induction Interferons Antiproliferative effect Cell Division medicine.drug |
| Zdroj: | Biochemical and biophysical research communications. 107(2) |
| ISSN: | 0006-291X |
| Popis: | Interferon (IFN) induces 2′–5′ oligo (A) synthetase both in P 3 HR-1 cells and spleen lymphocytes. Both cell types are sensitive to the antiproliferative effect of IFN, shown by accumulation of cells in G 0 /G 1 . However, the reaction product of the synthetase does not mimic the effect of IFN on cell cycle parameters, rather it inhibits progression through S. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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