N-Acylhydrazones as inhibitors of PDE10A

Autor:	László Ürögdi, Alex Rohde, Jennifer Lynn Gage, Sasha Gragerov, György Dormán, Rene Onrust, Vince Florio, Neil S. Cutshall, Derek Johnston, Andrew Osnowski, Harbol Kevin L, Thomas Neil Wheeler, Lee Mitchell, Wendy MacDonald
Rok vydání:	2011
Předmět:	Phosphodiesterase Inhibitors Stereochemistry Clinical Biochemistry Pharmaceutical Science Hydrazone Hydrazide Biochemistry Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Humans Structure–activity relationship Molecular Biology chemistry.chemical_classification biology Bicyclic molecule Phosphoric Diester Hydrolases Chemistry Organic Chemistry Hydrazones Phosphodiesterase Rats Disease Models Animal Enzyme Enzyme inhibitor Quinolines Schizophrenia biology.protein Molecular Medicine PDE10A
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 21:4155-4159
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2011.05.100
Popis:	Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e228427176a466f0fe79d22fac4b0b4 https://doi.org/10.1016/j.bmcl.2011.05.100 Zobrazit plný text záznamu Full Text from ScienceDirect