Evaluation of a point-of-care benchtop analyzer for quantitative measurement of C-reactive protein in canine serum and plasma

Autor:	Sara L. Connolly, Phil Solter, Joo Hoo Don, Kim Hyun Jeong, Peter D. Constable
Rok vydání:	2022
Předmět:	Inflammation Dogs C-Reactive Protein General Veterinary Point-of-Care Testing Point-of-Care Systems Animals Reproducibility of Results Dog Diseases Acute-Phase Proteins
Zdroj:	Veterinary clinical pathologyREFERENCES. 51(4)
ISSN:	1939-165X
Popis:	Canine C-reactive protein (cCRP) is an acute-phase protein that increases dramatically with inflammation and has potential utility in monitoring disease progression and response to treatment. Rapid, automated point-of-care test (POCT) formats could enhance the clinical utility of cCRP measurement.We aimed to evaluate the VetChroma canine-specific POCT assay for the quantitative measurement of cCRP in canine serum or plasma.Serum and plasma from discarded canine diagnostic samples were used. Evaluation included intra- and inter-assay coefficients of variation and observed total error (TEIntra-assay variation ranged from 2.5%-6.1%, and inter-assay variation ranged from 2.1%-5.4%. The TEThe VetChroma cCRP assay has acceptable test performance to measure serum cCRP concentration. The POCT protocol and test kit are valid for clinical use, although results obtained using other cCRP assays or plasma may not be directly compared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1ffdaadb62787623577fa033016d56 https://pubmed.ncbi.nlm.nih.gov/35578379 Zobrazit plný text záznamu Plný text