Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children
| Autor: | Cengiz Kara, Erdal Eren, Murat Aydin, Ahmet Uçaktürk, Behzat Özkan, Abdullah Bereket, Mustafa Kendirci, Ahmet Anık, Atilla Cayir, Gülay Can Yılmaz, Hakan Doneray, Ayça Törel Ergür, Semra Cetinkaya, Zerrin Orbak, Zeynep Atay, Korcan Demir, Zehra Aycan |
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| Přispěvatelé: | OMÜ, Demir, Korcan, Doneray, Hakan, Kara, Cengiz, Atay, Zeynep, Cetinkaya, Semra, Cayir, Atilla, Anik, Ahmet, Eren, Erdal, Ucakturk, Ahmet, Yilmaz, Gulay Can, Ergur, Ayca Torel, Kendirci, Mustafa, Aycan, Zehra, Bereket, Abdullah, Aydn, Murat, Orbak, Zerrin, Ozkan, Behzat, Kırıkkale Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism INFANTS Pamidronate Parathyroid hormone THERAPY lcsh:Diseases of the endocrine glands. Clinical endocrinology Gastroenterology TOXICITY 0302 clinical medicine Endocrinology over-the-counter drugs rickets 030212 general & internal medicine Vitamin D ALENDRONATE RISK Bone Density Conservation Agents steroid lcsh:RJ1-570 Vitamins Prognosis Prednisolone Alkaline phosphatase Female Original Article medicine.drug medicine.medical_specialty Hypercalcaemia Pediatric endocrinology chemistry.chemical_element Rickets Calcium D DEFICIENCY 03 medical and health sciences 030225 pediatrics Internal medicine medicine Humans stoss therapy Retrospective Studies Nutrition lcsh:RC648-665 business.industry Infant lcsh:Pediatrics Retrospective cohort study medicine.disease PREVENTION chemistry Pediatrics Perinatology and Child Health Hypercalcemia business Follow-Up Studies |
| Zdroj: | JCRPE, Vol 11, Iss 2, Pp 140-148 (2019) Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| DOI: | 10.4274/jcrpe.galenos.2018.2018.0131 |
| Popis: | Eren, Erdal/0000-0002-1684-1053; yilmaz, gulay can/0000-0003-0525-1231; Demir, Korcan/0000-0002-8334-2422; UCAKTURK, Seyit Ahmet/0000-0001-8666-4454; Kara, Cengiz/0000-0002-8989-560X WOS: 000469271100005 PubMed: 30396880 Objective: No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment results. Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia (serum calcium level > 10.5 mg/dL) due to vitamin D intoxication [serum 25-hydroxyvitamin D (25(OH)D) level > 150 ng/mL] who were treated in pediatric endocrinology clinics. Results: Seventy-four children [median (range) age 1.06 (0.65-1.60) years, 45 males (61 %) from II centers] were included. High-dose vitamin D intake was evident in 77% of the cases. At diagnosis, serum calcium, phosphorus, alkaline phosphatase, 25(OH)D and parathyroid hormone concentrations were 15 +/- 3.2 mg/dl., 5.2 +/- 1.2 mg/dL, 268 +/- 132 IU/L, 322 (236-454) ng/ml, and 5.5 (3-10.5) pg/mL, respectively. Calcium levels showed moderate correlation with 25(OH)D levels (r(s) = 0.402, p |
| Databáze: | OpenAIRE |
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