Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis
| Autor: | Jay L. Degen, Qing Xiao, Maria T. Valentine, David P. Witte, Mark C. Kowala, Thomas H. Bugge, Mary Jo S. Danton |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty Apolipoprotein B Arteriosclerosis Aorta Thoracic Context (language use) Fibrin Mice chemistry.chemical_compound Apolipoproteins E medicine.artery Plasminogen Activator Inhibitor 1 medicine Animals Genetic Predisposition to Disease Vascular Diseases Aorta Multidisciplinary biology Plasminogen Lipid metabolism Biological Sciences medicine.disease Urokinase-Type Plasminogen Activator Cellular infiltration chemistry Plasminogen activator inhibitor-1 Immunology biology.protein |
| Zdroj: | Proceedings of the National Academy of Sciences. 94:10335-10340 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.94.19.10335 |
| Popis: | A critical link between hemostatic factors and atherosclerosis has been inferred from a variety of indirect observations, including the expression of procoagulant and fibrinolytic factors within atherosclerotic vessels, the presence of fibrin in intimal lesions, and the cellular infiltration of mural thrombi leading to their incorporation into developing plaques. To directly examine the role of the key fibrinolytic factor, plasminogen, in atherogenesis, plasminogen-deficient mice were crossed to hypercholesterolemic, apolipoprotein E-deficient mice predisposed to atherosclerosis. We report that the loss of plasminogen greatly accelerates the formation of intimal lesions in apolipoprotein E-deficient animals, whereas plasminogen deficiency alone does not cause appreciable atherosclerosis. These studies provide direct evidence that circulating hemostatic factors strongly influence vessel wall disease in the context of a disorder in lipid metabolism. |
| Databáze: | OpenAIRE |
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