Risk Factors for Basal Cell Carcinoma in Men Younger Than 40 Years: A Case–Control Study
| Autor: | Tyler M. Bauman, Alan S. Boyd, Kathleen M. Nemer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Dermatology Malignancy 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors Surveys and Questionnaires Internal medicine Biopsy medicine Carcinoma Humans Genetic Predisposition to Disease Basal cell carcinoma Family history skin and connective tissue diseases Retrospective Studies integumentary system medicine.diagnostic_test business.industry Age Factors Case-control study Retrospective cohort study General Medicine medicine.disease Carcinoma Basal Cell Case-Control Studies 030220 oncology & carcinogenesis Sunlight Surgery Skin cancer business Sunscreening Agents |
| Zdroj: | Dermatologic Surgery. 44:1373-1378 |
| ISSN: | 1524-4725 1076-0512 |
| Popis: | Background Basal cell carcinoma (BCC) is the most common malignancy in the United States and is more prevalent in older populations. Objective The aim of this study was to investigate BCC risk factors in male patients younger than 40 years. Materials and methods A consecutive series of male patients with pathology-proven BCC and younger than 40 years at time of diagnosis were retrospectively identified along with matched controls. Phone interviews were conducted using a structured questionnaire, and differences between patients with and without BCC were investigated. Results A total of 50 patients with BCC and 27 controls were included in this study. Compared with controls, patients with BCC worked outdoor jobs for longer lengths of time (43.2 vs 15.6 months; p = .04), were more likely to have a family history of skin cancer (66% vs 44%; p = .02), and were more likely to use sunscreen heavily after biopsy (p = .02). Patients with multiple BCCs (n = 20) were more likely to have a history of substantial recreational sun exposure (p = .01) than patients with solitary lesions (n = 30). Conclusion The authors conclude that outdoor sun exposure in patients with underlying genetic susceptibility is the most likely mechanism of BCC formation in young male patients. |
| Databáze: | OpenAIRE |
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