BIOLOGICAL EFFECTS OF THE METABOLITES OF DIMETHYL SULFOXIDE*
| Autor: | Robert Snyder, S. Harkaway, J. J. Kocsis |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Taurine
Time Factors Metabolite Sulfur Oxides Motor Activity General Biochemistry Genetics and Molecular Biology Body Temperature Sulfone Lethal Dose 50 Mice chemistry.chemical_compound History and Philosophy of Science medicine Animals Hypnotics and Sedatives Organic chemistry Dimethyl Sulfoxide Paraoxon Dimethyl sulfoxide organic chemicals General Neuroscience Benzene Drug Synergism Hydrocarbons Rats Solvent Tranquilizing Agents chemistry Depression Chemical Toxicity Dimethyl sulfide Cholinesterase Inhibitors medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 243:104-109 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1975.tb25349.x |
| Popis: | In summary, the effects of dimethyl sulfoxide (DMSO) and its metabolites, dimethyl sulfone (DMSO2) and dimethyl sulfide (DMS), were studied in five selected systems in rats and mice. DMSO enhanced the taurine excretion and the lethality produced by such aromatic hydrocarbons as benzene and chlorobenzene in rats. In mice, DMSO decreased the toxicity such cholinesterase inhibitors as paraoxon and octamethyl pyrophosphoramide. DMSO also lowered the body temperture of rats and reduced the motor activity of mice. Although DMSO2, the major metabolite of DMSO, was not effective in increasing the lethality of solvent hydrocarbons, it seemed to be quite as effective with respect to the other effects. DMS, although quite potent with respect to lowering body temperature and reducing motor activity, was relatively ineffective otherwise. Thus each of the metabolites has a spectrum of activity different from the parent compound; DMSO has the widest spectrum and DMS the narrowest. It remains to be determined whether the therapeutic effects of DMSO are related to the experimental effects reported above in animals, and whether DMSO2 and DMS may share any of the therapeutic effects of DMSO. |
| Databáze: | OpenAIRE |
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