New rhodamine nitroxide based fluorescent probes for intracellular hydroxyl radical identification in living cells
| Autor: | K. Michael Gibson, Steffen Jockusch, Yasuhiro Itagaki, Sherri L. Wiseman, Nicholas J. Turro, Srinivas Rao Mandalapu, Nazmiye Bihter Yapici, Lanrong Bi, Alberto Moscatelli, Dallas K. Bates |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Nitroxide mediated radical polymerization Molecular Structure Cell Survival Hydroxyl Radical Rhodamines Radical Organic Chemistry Intracellular Space Photochemistry Biochemistry Fluorescence Cell Line Rhodamine chemistry.chemical_compound Oxidative Stress chemistry Molecule Humans Hydroxyl radical Nitrogen Oxides Physical and Theoretical Chemistry Selectivity Fluorescent Dyes |
| Zdroj: | Organic letters. 14(1) |
| ISSN: | 1523-7052 |
| Popis: | The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate •OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for •OH detection. |
| Databáze: | OpenAIRE |
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