A general preparation of (Z)-1-fluorostilbene derivatives for the design of conformationally restricted peptidomimetics

Autor:	David R. Williams, Thomas E. Christos, Jeffery S. Carter, Micheal W. Fultz
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Chemistry Peptidomimetic Aryl Organic Chemistry Drug Discovery Biochemistry Combinatorial chemistry Article Stille reaction
Zdroj:	Tetrahedron letters. 51(6)
ISSN:	0040-4039
Popis:	The preparation of (Z)-1-fluoro-2-bromostyrenes provides a general route for the formation of (Z)-1-fluorostilbene derivatives as configurationally stable spacial linkers for the design of conformationally restricted peptidomimetics. Palladium-catalyzed aryl Suzuki and Stille cross-coupling reactions have been surveyed to proceed with complete retention of fluoroalkene geometry, and permit the direct incorporation of a variety of aryl and heteroaromatic substituents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e182e6e4d8a623f3702fc079b5f20c6 https://pubmed.ncbi.nlm.nih.gov/23397337 Zobrazit plný text záznamu Full Text from ScienceDirect