A general preparation of (Z)-1-fluorostilbene derivatives for the design of conformationally restricted peptidomimetics

Autor: David R. Williams, Thomas E. Christos, Jeffery S. Carter, Micheal W. Fultz
Rok vydání: 2013
Předmět:
Zdroj: Tetrahedron letters. 51(6)
ISSN: 0040-4039
Popis: The preparation of (Z)-1-fluoro-2-bromostyrenes provides a general route for the formation of (Z)-1-fluorostilbene derivatives as configurationally stable spacial linkers for the design of conformationally restricted peptidomimetics. Palladium-catalyzed aryl Suzuki and Stille cross-coupling reactions have been surveyed to proceed with complete retention of fluoroalkene geometry, and permit the direct incorporation of a variety of aryl and heteroaromatic substituents.
Databáze: OpenAIRE