The effect of stress and indomethacin, carbenoxolone, salbutamol, metiamide, zolimidine and CF19415 on rat gastric mucus
| Autor: | D H Turner, A P Green, J E Lander |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Acetonitriles Pyridines Indomethacin Carbenoxolone Pharmaceutical Science Metiamide Zolimidine chemistry.chemical_compound Stress Physiological Internal medicine medicine Gastric mucosa Animals Secretion Albuterol Stomach Ulcer Pharmacology Chemistry respiratory system Reserpine Anti-Ulcer Agents Mucus Rats medicine.anatomical_structure Endocrinology Gastric Mucosa Salbutamol medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 33(6) |
| ISSN: | 0022-3573 |
| Popis: | A method for measuring mucus adherent to the gastric mucosa using the dye alcian blue has been evaluated. Mucus was reduced by cold-restraint stress, reserpine and pyloric ligation, but not by 18 h fasting or indomethacin. The fasting mucus level was increased by carbenoxalone, but not by salbutamol or metiamide, and zolimidine only prevented the reduction in mucus induced by stress. A novel compound, 2-α-methoxyiminopyrazine acetonitrile (CF 19415), at 100 mg kg−1 orally increased alcian blue binding in fasted rats and in a cold restraint test, 100 mg kg−1 orally inhibited gastric damage and stimulated mucus secretion. |
| Databáze: | OpenAIRE |
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