Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease
| Autor: | Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P, FORTI, PAOLA |
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| Přispěvatelé: | Lambert, J, Heath, S, Even, G, Campion, D, Sleegers, K, Hiltunen, M, Cambarros, O, Zelenika, D, Bullido, M, Tavernier, B, Letenneur, L, Bettens, K, Berr, C, Pasquier, F, Fiévet, N, Barbager Gateau, P, Engelborghs, S, De Deyn, P, Mateo, I, Franck, A, Helisalmi, S, Porcellini, E, Hanon, O, the European Alzheimer’s disease Initiative, I, de Pancorbo, M, Lendon, C, Dufouil, C, Jaillard, C, Leveillard, T, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Hannequin, D, Licastro, F, Soininen, H, Ritchie, K, Blanché, H, Dartigues, J, Tzourio, C, Gut, I, Broeckhoven, C, Alpérovitch, A, Lathrop, M, Amouyel, P, Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative Investigator, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P, Electronics and Informatics, Clinical sciences, Neurology, Pathologic Biochemistry and Physiology |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Apolipoprotein E
SORL1 Genome-wide association study Disease Polymorphism Single Nucleotide White People ABCA7 PICALM Alzheimer Disease Genetics Humans Genetic Predisposition to Disease European Continental Ancestry Group/genetics Alzheimer's disease genome-wide association APOE APOJ Medicine(all) Alzheimer Disease/genetics biology Phosphatidylinositol binding Clusterin Haplotypes Receptors Complement 3b biology.protein Human medicine Clusterin/genetics Receptors Complement 3b/genetics Genome-Wide Association Study |
| Zdroj: | Nature genetics |
| ISSN: | 1061-4036 |
| Popis: | The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P 10 5) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 × 10 9 for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 × 10 9 for combined data). Previous biological studies support roles of CLU and CR1 in the clearance of Β amyloid (AΒ) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease. © 2009 Nature America, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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