New sol-gel-derived magnetic bioactive glass-ceramics containing superparamagnetic hematite nanocrystals for hyperthermia application
| Autor: | Roger Borges, Francesco Baino, Juliana Marchi, C. Rettori, L. Mendonça-Ferreira, Isis S.O. Pereira |
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| Rok vydání: | 2020 |
| Předmět: |
Ceramics
Materials science Simulated body fluid Hematite Nanoparticle Maghemite Bioengineering Biocompatible Materials 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Ferric Compounds law.invention Biomaterials chemistry.chemical_compound Bioactive glass-ceramic Hyperthermia Sol-gel Superparamagnetism Glass Humans Magnetic Iron Oxide Nanoparticles Magnetic Phenomena Nanoparticles law Bone regeneration Magnetite 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering chemistry Mechanics of Materials Bioactive glass visual_art engineering visual_art.visual_art_medium 0210 nano-technology |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 120 |
| ISSN: | 1873-0191 |
| Popis: | Although the three main phases of iron oxide – hematite, maghemite, and magnetite – exhibit superparamagnetic properties at the nanoscale, only maghemite and magnetite phases have been explored in magnetic bioactive glass-ceramics aimed at applications in cancer treatment by hyperthermia. In this work, it is reported for the first time the superparamagnetic properties of hematite nanocrystals grown in a 58S bioactive glass matrix derived from sol-gel synthesis. The glass-ceramics are based on the (100-x)(58SiO2-33CaO-9P2O5)-xFe2O3 system (x = 10, 20 and 30 wt%). A thermal treatment leads to the growth of hematite (α-Fe2O3) nanocrystals, conferring superparamagnetic properties to the glass-ceramics, which is enough to produce heat under an external alternating magnetic field. Besides, the crystallization does not inhibit materials bioactivity, evidenced by the formation of calcium phosphate onto the glass-ceramic surface upon soaking in simulated body fluid. Moreover, their cytotoxicity is similar to other magnetic bioactive glass-ceramics reported in the literature. Finally, these results suggest that hematite nanocrystals' superparamagnetic properties may be explored in multifunctional glass-ceramics applied in bone cancer treatment by hyperthermia allied to bone regeneration. |
| Databáze: | OpenAIRE |
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