Thymocyte Selection: Chemokine Signaling Is Not Only about the Destination
| Autor: | Michael Gleimer, Harald von Boehmer |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
CCR1
Receptors CXCR4 T-Lymphocytes Apoptosis CCR8 Biology Lymphocyte Activation General Biochemistry Genetics and Molecular Biology Animals Humans CCL17 CCL13 Cell Proliferation Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Models Immunological Cell Differentiation Chemokine CXCL12 Cell biology Chemotaxis Leukocyte CXCL9 CCL27 Chemokines CCL25 General Agricultural and Biological Sciences Signal Transduction CCL21 |
| Zdroj: | Current Biology. 20(7):R316-R318 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2010.02.018 |
| Popis: | Summary The development and function of lymphocytes depend upon their precise migration in response to chemoattractant cytokines, or chemokines. Two recent reports suggest that, during thymic β-selection, the binding of the chemokine CXCL12 to the receptor CXCR4 on thymocytes provides not only directional but also developmental cues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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