Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance
| Autor: | Juan Carlos de Vicente, Manuel F. Fresno, Juan Sebastián López-Arranz, Agustı́n Herrero-Zapatero |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Risk Cancer Research Pathology medicine.medical_specialty Cell Cyclin D1 Biomarkers Tumor Humans Medicine Basal cell Lymph node Aged Neoplasm Staging Aged 80 and over Analysis of Variance biology business.industry Middle Aged Prognosis Immunohistochemistry Neoplasm Proteins Survival Rate Ki-67 Antigen medicine.anatomical_structure Oncology Epidermoid carcinoma Lymphatic Metastasis Ki-67 Carcinoma Squamous Cell biology.protein Female Mouth Neoplasms Oral Surgery business NODAL Follow-Up Studies |
| Zdroj: | Oral Oncology. 38:301-308 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/s1368-8375(01)00060-4 |
| Popis: | The prognostic and clinicopathologic significance of cyclin D1 and Ki-67 expressions was studied in oral squamous cell carcinomas. We performed an immunohistochemical study to determine the level of expression of cyclin D1 and Ki-67 labelling index in tumor specimens obtained from 35 patients, of whom 14 died as a result of recurrent disease, and 20 were free of recurrence at the end of the follow-up period. Overexpression of cyclin D1 was significantly associated with regional lymph node metastases ( P =0.00005) and advanced tumor stage ( P =0.0007). The relative risk for nodal metastases in the cases that overexpressed cyclin D1 was 2.6. The Ki-67 labelling index was significantly ( P =0.001) higher in tumors with poor histologic grade of differentiation. Our results showed that cyclin D1 is a useful prognostic factor, and suggested it could be a marker to help determine the appropiate treatment for patients with oral squamous cell carcinoma. Cyclin D1 and Ki-67 overexpression were positively correlated. |
| Databáze: | OpenAIRE |
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