Selective synthesis of ureas and tetrazoles from amides controlled by experimental conditions using conventional and microwave irradiation
| Autor: | Andiappan Lavanya, Maruthan Kirubavathi, Vediappen Padmini, Rajendran Sribalan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Reaction conditions
Chemistry(all) 010405 organic chemistry Chemistry Tetrazoles One pot conversion General Chemistry Carbon-13 NMR 010402 general chemistry 01 natural sciences 0104 chemical sciences Solvent lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 Microwave synthesis Yield (chemistry) Amide Microwave irradiation Proton NMR Organic chemistry Substituted urea In situ synthesis Microwave |
| Zdroj: | Journal of Saudi Chemical Society, Vol 22, Iss 2, Pp 198-207 (2018) |
| ISSN: | 1319-6103 |
| DOI: | 10.1016/j.jscs.2016.03.004 |
| Popis: | An efficient synthetic procedure has been achieved for selective synthesis of 1,5-disubstituted tetrazoles and diaryl ureas from secondary amides in situ in the presence of NaN 3 and POCl 3 as solvent, both by conventional and microwave methods. The reaction conditions were optimized to yield selectively either tetrazoles or urea derivatives from reasonable to excellent yields. These conversions have been tested and verified with various secondary amide precursors. The synthesized compounds were characterized by 1 H NMR, 13 C NMR and ESI-MS spectroscopic techniques. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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