Hydrofilm Polyurethane Films Reduce Radiation Dermatitis Severity in Hypofractionated Whole-Breast Irradiation: An Objective, Intra-Patient Randomized Dual-Center Assessment †

Autor:	Christina Leitzen, Dorothea Kunze, David Koch, Leonard Christopher Schmeel, Hans H. Schild, Birgit Mahlmann, Felix Schoroth, Martina Heimann, Alina-Valik Abramian, Timo Wilhelm-Buchstab, Stephan Garbe, Dilini Brüser, Fred Röhner, Thomas Müdder, Frederic Carsten Schmeel, Bettina Bücheler, B. Baumert
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	film dressing medicine.medical_specialty Polymers and Plastics Erythema Side effect medicine.medical_treatment whole-breast irradiation Article 030218 nuclear medicine & medical imaging Hydrofilm 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer medicine business.industry hypofractionation Common Terminology Criteria for Adverse Events General Chemistry medicine.disease radiation dermatitis Dermatology Hyperpigmentation Radiation therapy Moist desquamation 030220 oncology & carcinogenesis Itching medicine.symptom business erythema
Zdroj:	Polymers Volume 11 Issue 12
ISSN:	2073-4360
Popis:	Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective skin products such as dressings are undoubtedly the standard of care in wound care management, their utilization as preventive treatment in radiotherapy has been somewhat neglected in recent years. In this prospective, intra-patient randomized observational study, Hydrofilm polyurethane films were prophylactically applied to either the medial or lateral breast-half of 74 patients with breast cancer undergoing hypofractionated whole-breast irradiation following breast-preserving surgery. Maximum radiation dermatitis severity was assessed using Common Terminology Criteria for Adverse Events (CTCAE) v4.03 toxicity scores, photospectrometric erythema and pigmentation measurements and patient-assessed modified Radiation-Induced Skin Reaction Assessment Scale (RISRAS) scale. Phantom studies revealed a clinically negligible dose build-up of less than 0.1% with Hydrofilm. Compared to the control compartments physician-assessed radiation dermatitis severity was reduced in the hydrofilm compartments (mean 0.54 vs. 1.34 p = < 0.001). Objective photospectrometric skin measurements showed decreased erythema (p = 0.0001) and hyperpigmentation (p = 0.002) underneath Hydrofilm. Hydrofilm also completely prevented moist desquamation, and significantly reduced patients&rsquo treatment-related symptoms of itching, burning, pain, and limitations of day-to-day-activities. Significant beneficial effects were observed in terms of radiation dermatitis severity, erythema, hyperpigmentation as well as subjective treatment-related symptom experiences, while adverse reactions were rare and minor. Therefore, a prophylactic application of Hydrofilm polyurethane films can be suggested in hypofractionated WBI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e131cc6d03a879ab49d6eec2fefaca3 http://europepmc.org/articles/PMC6960998 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.