Effect of 5-HT2 Receptor Blockade on Cadmium-Induced Acute Toxicity
| Autor: | Rosa I. Hereti, Konstantinos N. Tzirogiannis, Georgia A. Manta, Georgios I Panoutsopoulos, Spyridon D. Skaltsas, Maria D. Demonakou, Michael G. Mykoniatis, George K. Papadimas, Kalliopi T. Kourentzi, Katerina N. Alexandropoulou |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Ketanserin Necrosis Physiology Apoptosis Ritanserin Internal medicine In Situ Nick-End Labeling medicine Animals Rats Wistar Liver injury TUNEL assay Chemistry Gastroenterology Liver Failure Acute medicine.disease Rats Disease Models Animal Treatment Outcome medicine.anatomical_structure Endocrinology Hepatocyte Toxicity Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists medicine.symptom Receptors Serotonin 5-HT2 Cadmium medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 52:2351-2358 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-006-9132-2 |
| Popis: | The protective effect of 5-HT(2) receptor blockade with ketanserin or ritanserin against cadmium liver injury was investigated. Male Wistar rats were injected intraperitoneally with a sublethal dose of cadmium (3.5 mg/kg body weight). Rats were treated with normal saline (group I), ketanserin (3 mg/kg body weight; group II), or ritanserin (3 mg/kg body weight; group III) 2 hr prior and 4 hr after cadmium administration and killed at different time points. Hematoxylin/eosin-stained liver sections were assessed for necrosis, apoptosis, peliosis, mitoses, and inflammatory infiltration. Apoptosis was also quantified by the TUNEL assay. Nonparenchymal liver cells and activated Kupffer cells were identified histochemically. Necrosis, hepatocyte apoptosis, nonparenchymal cell apoptosis, and macroscopic and microscopic peliosis were markedly reduced or minimized in ketanserin- or ritanserin-treated rats. The observed protective effect was almost identical for both ketanserin and ritanserin administration. 5-HT(2) receptor blockade exerts a protective effect against acute cadmium-induced hepatotoxicity. |
| Databáze: | OpenAIRE |
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