Efficacy of compartmentalization in controlling an adenovirus type 54 keratoconjunctivitis outbreak on Oki Island, Japan
| Autor: | Yumiko Shimizu, Yoshitsugu Inoue, Tsuguto Fujimoto, Kazuki Matsuura, Yutaka Omatsu, Shin-ichi Sasaki, Eiichi Uchio, Dai Miyazaki |
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| Rok vydání: | 2021 |
| Předmět: |
Keratoconjunctivitis
Biology Adenoviridae Disease Outbreaks Incubation period Adenovirus Infections Human Japan Basic reproductive number Humans Infection control Clinical Investigation Adenovirus type 54 Susceptible-exposed-infectious-recovered model Child Index case Retrospective Studies Incidence (epidemiology) Epidemic keratoconjunctivitis Outbreak Retrospective cohort study General Medicine Virology Epidemic Keratoconjunctivitis Ophthalmology Compartmentalization Basic reproduction number |
| Zdroj: | Japanese Journal of Ophthalmology |
| ISSN: | 1613-2246 0021-5155 |
| DOI: | 10.1007/s10384-021-00826-8 |
| Popis: | Purpose To analyze the epidemiologic characteristics of an outbreak of human adenovirus type 54 (HAdV-54) on Oki Island, Shimane Prefecture, Japan, in 2017 and to assess the effectiveness of a compartmentalization method in controlling the incidence and spread. Study design Retrospective cohort study. Methods The infection was diagnosed in 136 individuals, and typing was confirmed by PCR and direct sequencing. The epidemiologic characteristics of the disease including the infection rate, incubation period, and basic reproductive number (R0), ie, number of cases directly infected by an infectious patient during the course of the disease, were investigated. The effectiveness of compartmentalization for infection control was determined by simulating the outbreak using the Susceptible-Exposed-Infectious-Recovered (SEIR) model. Results The majority of the HAdV-54-infected individuals were the children of 3 nursery schools (A, B, and C) and their parents on Oki Island. The infection rates in the 3 schools were 13.2%, 16.9%, and 17.2%, respectively. The one class of school B without the index case was initially compartmentalized, and the infection rate in this compartment was 0%. The incubation period was calculated to be 9.3 ± 3.5 days, and the disease duration, 13.0 ± 5.4 days. The R0 was 1.43. Using these parameters, a SEIR model was constructed. The SEIR model well predicted the daily incidence of infection and indicated that the compartmentalization method provides effective reduction in the incidence of the infection, with much earlier control. Conclusions The compartmentalization method is effective to control HAdV-54 outbreaks. Supplementary Information The online version contains supplementary material available at 10.1007/s10384-021-00826-8. |
| Databáze: | OpenAIRE |
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